RESEARCH PROJECT IN HIV VARIABILITY

This research project is aimed to study genetic variation in HIV-1 envelope glycoprotein gp120.

1996-January 2008: Research Director, Laboratory of AIDS Immunopathogenesis, Division of Immunology and Allergy, CHUV, Lausanne. 1993-1996: Visiting Scientist, Laboratory of Immunoregulation, NIAID, NIH, Maryland, USA. 1990-1993: Expert, LIR, NIAID, NIH, USA.

Elisa De Crignis, Ph. D. Research Fellow April 2010-present: Research Fellow, Division of Immunology and Allergy, CHUV, Lausanne.

2007-2010: PhD in Medical Biotechnology at the University of Bologna. Research focus: Antiretroviral activity of cystatins 2004-2006: Master’s Degree in Health Sciences, University of Bologna. Research focus: Bone abnormalities during HIV infection. 2001-2004: Bachelor’s Degree in Biology, University of Bologna. Research focus: p63 splicing variants in squamous cell carcinoma.

Awards:

• 1994:
  Special Achievement, US Department of Health and Human Services
   
• 1996:
  National Institutes of Health Award of Merit

Selected publications:

• De Crignis E., Guglietta S., Foley B.T., Negroni M., Di Narzo A.F., Waelti Da Costa V., Cavassini M.,
  Bart P.-A., Pantaleo G. and Graziosi C.
  Non-random distribution of cryptic repeating triplets of purines and pyrimidines (RNY)n
  in gp120 of HIV-1. AIDS Res. Hum. Retrov. In press.
   
• Guglietta S., Pantaleo G. and Graziosi C.
  Long sequence duplications, repeats and palindromes in HIV-1 gp120: length variation in V4 as the product of misalignment mechanism.
  Virology 2010, 399:178-186.
   
• Bélair M., Dovat M., Foley B., Mayerat C., Pantaleo G. and Graziosi C.
  The polymorphic nature of HIV type 1 env V4 affects the patterns of potential N-glycosylation sites in proviral DNA at the intrahost level.
  AIDS Res. Hum. Retroviruses 2009, 25:199-206.
   
• Castro E., Bélair M., Rizzardi G.P., Bart P.-A., Pantaleo G. and Graziosi C.
  Independent evolution of hypervariable regions of human immunodeficiency virus type I (HIV-1) gp120: V4 as a swarm of N-linked glycosylation variants.
  AIDS Res. Hum. Retroviruses 2008, 24:106-113.
   

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