MUCOSAL IMMUNITY

• Mucosal immunology and secretory immunoglobilin A: General concepts
  (Blaise Corthésy)
   
• Entry of secretory immunoglobulin into Peyer's patch M cells: targeting of dentritic cells and immunomodulatory properties
  (Laurent Favre, Jacques Rey, Blaise Corthésy)
   
• Secretory IgA-mediated neutralization of Shigella flexneri prevents intestinal tissue destruction by inhibiting inflammatory circuits
  (Khalil Kadaoui, Blaise Corthésy, in collaboration with Armelle Phalipon and Philippe Sansonetti, Institut Pasteur Paris, France, and Séverine Boullier, INRA, Toulouse, France)
   
• Impact of antigen binding on structural features of secretory IgA
  (Blaise Corthésy, in collaboration with Finn-Eirik Johansen, University of Oslo, Norway)
   
• Possible role of secretory IgA controlling commensal homeostasis in the intestine
  (Blaise Corthésy)
   
• Protective and anti-inflammatory properties of SIgA in human intestinal epithelial cells
  (Amandine Mathias, Blaise Corthésy)
   
• Determination of the solution structure of free human secretory component
  (Blaise Corthésy, Clémentine Perrier, IAL-CHUV, in collaboration with: Steven Perkins and Alexandra Bonner, Department of Biochemistry, University College London, London, U.K.)
   
• Development of in vivo and in vitro models to study the role of SIgA in modulating allergic types of immune responses
  (Clémentine Perrier, Anne-Christine Thierry, Blaise Corthésy, in collaboration with Annick Mercenier, Nestec Research Centre, Lausanne)
   
• Investigation of mechanisms leading to gastropathology in HIV-infected patients.
  (Selena Vigano, Matthieu Perreau, Alexandre Harari)